Organ Transplant
When an organ is removed from a donor, it loses its blood and oxygen supply (a state called ischemia). Without intervention, the cells would rapidly deplete their energy, fill with fluid, turn acidic, and die. Solutions like VitaOrgaSol and Custodiol HTK prevent this damage by putting the cells into a state of “suspended animation” and defending them against chemical breakdowns.
Cellular Deactivation
Low Sodium and Calcium: Normal cell function requires constantly pumping sodium out and pulling potassium in, which consumes a lot of cellular energy. By removing almost all sodium and calcium from the fluid outside the cells, the solution stops this process. It hyperpolarizes the cell membranes, forcing the cells into a state of deep rest to lower energy demands.
Acidosis Control
Without oxygen, cells switch to anaerobic metabolism to survive, which produces lactic acid as a waste product.Lactic acid causes the tissue environment to become highly acidic, which destroys cell structures.Histidine acts as a powerful buffer that absorbs the acidic hydrogen ions, keeping the pH steady and allowing the cells to survive oxygen deprivation for hours.
Fighting Cellular Swelling
When cell pumps fail due to a lack of oxygen, water rushes into the cells, causing them to swell and burst (edema). Mannitol is a sugar alcohol that creates a strong osmotic pull outside the cells. It effectively acts as a sponge, pulling water back out to prevent cellular swelling and keep the microscopic blood vessels from collapsing.
Membrane Protection
Cold temperatures and lack of oxygen make the fatty outer walls of cells rigid and prone to tearing. Tryptophan acts as a direct membrane stabilizer, helping to keep the outer cellular wall intact during transport.The most dangerous phase for a transplanted organ is actually when blood flow is restored in the recipient
VitaOrgaSol – Liver Transplant Preservation Solution
VitaOrgaSol Histidine Tryptophan Ketoglutarate (HTK) Solution is a Class IIa medical device used for organ perfusion and preservation during transplantation. Packed in a PVC-free bag, it helps protect organs such as the liver, heart, kidney, lung, and pancreas.
Its advanced formulation provides strong buffering capacity, protects cell membranes, reduces tissue acidity, and enables rapid cooling with low viscosity for effective flushing. The low potassium (K+) content minimizes the risk of hyperkalemia and post-transplant complications, eliminating the need for flushing before transplantation.
VitaOrgaSol is easy to use, practical for medical teams, and considered a universal preservation solution for heart and abdominal organs. Manufactured in Italy by Galenica Senese, it is used only by trained medical professionals following standard transplant protocols.